An open, Phase 1, exploratory study of radiosensitization in patients with advanced carcinoma of the head and neck is underway and actively recruiting patients at 3 sites in the UK.
Part 1: to evaluate safety in a dose-escalation design in patients indicated for palliative radiotherapy
Part 2 to evaluate safety and efficacy in a dose-escalation design in patients indicated for cis-platin chemoradiotherapy
The protocol received a CTA from the UK MHRA in 2012 and the first patients were enrolled from September 2013 onwards. The lead investigator is Dr Stefano Schipani MD, The Institute of Cancer Sciences, University of Glasgow, Beatson West of Scotland Cancer Centre, along with Dr Bernie Foran, MD, Oncology Department, Weston Park Hospital, Sheffield and Dr Teresa Guerrero Urbano, MD, Guy’s and St Thomas’ Hospital, London.